Iranian Journal of Radiology Iranian Journal of Radiology Iran J Radiol http://www.Iranjradiol.portal.tools 1735-1065 2008-2711 10.5812/iranjradiol en jalali 2021 3 1 gregorian 2021 3 1 Special iss 5
en 10.5812/iranjradiol.48207 Does Myocardial Scan with Technetium Lead to Radio Adaptive Response Among Patients Who Are Undergoing Thallium Scan? (Cytogenetic Study) Does Myocardial Scan with Technetium Lead to Radio Adaptive Response Among Patients Who Are Undergoing Thallium Scan? (Cytogenetic Study) abstract abstract Conclusions

These findings suggest that exposure to Tc-99m could induce a radio-adaptive response against the exposure of Tl-201.

Background

Low dose radiation will induce adaptation and following exposure to an adaptive dose, the cells are more resistance to following challenging doses. This phenomenon is known as radio-adaptive response. The aim of this study was to investigate the percentage of apoptotic cells in the peripheral blood samples of the patients which undergo myocardial perfusion imaging with Tc-99m prior to thallium scan to assess the induction of radio-adaptive response.

Methods

97 samples from 74 patients, referred to nuclear medicine center of Mazandaran heart hospital for myocardial perfusion imaging which had no history of diagnostic, therapeutic, occupational and radioactive exposures during past two years, were provided. The participants were classified into four groups including control, technetium, thallium and the last group were the patients that examined by technetium followed by thallium. Then 2 mL Peripheral blood samples were obtained, the samples were studied by neutral comet assay with one-way ANOVA.

Results

The mean percent of apoptotic cells in the groups 2, 3, 4 were more than the controls and the mean percent of apoptotic cells in the patients who examined with 201Tl were more than other groups but the mean percent of apoptotic cells in the group 4 (99mTc before 201Tl) was less than that group 3(just examinated by 201Tl) and this difference was significant statistically.

Conclusions

These findings suggest that exposure to Tc-99m could induce a radio-adaptive response against the exposure of Tl-201.

Background

Low dose radiation will induce adaptation and following exposure to an adaptive dose, the cells are more resistance to following challenging doses. This phenomenon is known as radio-adaptive response. The aim of this study was to investigate the percentage of apoptotic cells in the peripheral blood samples of the patients which undergo myocardial perfusion imaging with Tc-99m prior to thallium scan to assess the induction of radio-adaptive response.

Methods

97 samples from 74 patients, referred to nuclear medicine center of Mazandaran heart hospital for myocardial perfusion imaging which had no history of diagnostic, therapeutic, occupational and radioactive exposures during past two years, were provided. The participants were classified into four groups including control, technetium, thallium and the last group were the patients that examined by technetium followed by thallium. Then 2 mL Peripheral blood samples were obtained, the samples were studied by neutral comet assay with one-way ANOVA.

Results

The mean percent of apoptotic cells in the groups 2, 3, 4 were more than the controls and the mean percent of apoptotic cells in the patients who examined with 201Tl were more than other groups but the mean percent of apoptotic cells in the group 4 (99mTc before 201Tl) was less than that group 3(just examinated by 201Tl) and this difference was significant statistically.

Myocardial Perfusion Imaging;Radio-Adaptive Response;Technetium;Thallium Myocardial Perfusion Imaging;Radio-Adaptive Response;Technetium;Thallium http://www.Iranjradiol.portal.tools/index.php?page=article&article_id=48207 Mohammmad Mehdi Shirazi Mohammmad Mehdi Shirazi Babol University of Medical Sciences, Babol, Iran; Babol University of Medical Sciences, Babol, Iran Babol University of Medical Sciences, Babol, Iran; Babol University of Medical Sciences, Babol, Iran Ali Shabestani Monfared Ali Shabestani Monfared Babol University of Medical Sciences, Babol, Iran Babol University of Medical Sciences, Babol, Iran Maryam Shahidi Maryam Shahidi Mazandaran University of Medical Sciences, Mazandaran, Iran Mazandaran University of Medical Sciences, Mazandaran, Iran Mehrangiz Amiri Mehrangiz Amiri Babol University of Medical Sciences, Babol, Iran Babol University of Medical Sciences, Babol, Iran